Aktivitas Antibakteri Kombucha Kulit Kayu Kemiri (Aleurites moluccana) Terhadap Propionibacterium acnes Sebagai Dasar Pengembangan Perawatan Antijerawat
Antibacterial Activity of Candlenut Stem Bark (Aleurites moluccana) Kombucha Against Propionibacterium acnes as Development of Anti-Acne Skin Care
DOI:
https://doi.org/10.30872/mpc.v19i.482Keywords:
Kombucha, Candlenut Stem Bark, AntibacterialAbstract
Jerawat adalah peradangan kronis pada kulit yang umumnya dipicu oleh Propionibacterium acnes. Perawatan jerawat yang menggunakan obat-obatan sintetis cenderung menimbulkan efek samping dan resistensi. Salah satu alternatifnya yaitu dengan produk probiotik hasil fermentasi seperti teh kombucha, yang potensinya dapat ditingkatkan dengan menambahkan kulit kayu kemiri selama proses fermentasi. Penelitian ini bertujuan untuk mengoptimasi pembuatan kombucha kulit kayu kemiri dan menguji aktivitas antibakterinya terhadap P. acnes. Tahapan metode diawali dengan fermentasi kombucha sebanyak 5 replikasi dengan perbandingan simplisia daun teh:kulit kayu kemiri antara lain 8:0 gram; 6:2 gram; 4;4 gram; 2:6 gram; dan 0:8 gram. Semua kombucha kemudian diuji aktivitas antibakterinya menggunakan metode mikrodilusi. Hasil pengujian menunjukkan bahwa kombucha dengan perbandingan 4:4 memiliki nilai kadar hambat minimal (KHM) yang tergolong sangat kuat yaitu 62,5 μg/mL serta memiliki aktivitas terbaik karena dapat menghambat hingga 98,89%. Oleh karena itu, dapat disimpulkan bahwa kombucha kulit kemiri dapat dikembangkan sebagai perawatan kulit antijerawat.
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