Sintesis 2’-Hidroksi-5’-Kloro-3,5-Dimetoksi-4-Hidroksikalkon

Authors

  • Amanuddin Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Hanggara Arifian Kelompok Bidang Ilmu Kimia Farmasi, Fakultas Farmasi, Universitas Mulawarman,Samarinda, Indonesia Author
  • Agung Rahmadani Kelompok Bidang Ilmu Kimia Farmasi, Fakultas Farmasi, Universitas Mulawarman,Samarinda, Indonesia Author
  • Rolan Rusli Kelompok Bidang Ilmu Kimia Farmasi, Fakultas Farmasi, Universitas Mulawarman,Samarinda, Indonesia Author https://orcid.org/0000-0003-1264-5933

DOI:

https://doi.org/10.30872/mpc.v11i.222

Keywords:

chalcone, 2'-hydroxy-5'-chloro acetophenone, syringaldehyde, 2'-hydroxy-5'-chloro-3,5-dimethoxy-4-hydroxicalcone

Abstract

Chalcone are compounds that have 2 aromatic rings connected by 3 carbon atoms which are an α, β unsaturated carbonyl system that have various biological activities. 2'-hydroxy-5'-chloro-3,5-dimethoxy-4-hydroxicalcone was synthesized from 2'-hydroxy-5'-chloro acetophenone and syringaldehyde using a NaOH catalyst. This compound was purified using Column Chromatography by isocratic method using n-hexane:ethyl acetate (15:1) as eluent. This compound has a Rf 0.75 and 2.7% of yield

References

[1] Espinoza, J.C., Rodriguez, L.M., Nevarez, G.V and Camacho, A. 2012. Synthesis, Experimental and Theoretical Study of the Spectroscopic Properties in (2E)-3-{3-methoxy-4-[(3-methyl but-2-en-1-yil)oxy]phenyl}-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one. Journal of Molecular Structure. 1020: 88-95.

[2] Kamble, V.M., Hatnapure, G.D., Keche, A.P., Birajdar, S., Patil, S.G., Tale, R.H., Rodge, A.H., Turkar, S.S. and Gour, K. 2011. Sintesis and Biological Evaluation of a Novel Series of Methoxylated Chalcones as Antioxidant and Anti-microbial agents. Journal. Chemistry. Pharmceutical. Research. 3(6):639-648.

[3] Kurniati, Yuharmen, Adel Zamri. 2015. Toksisitas Senyawa Analog Kalkon 3’-Metoksiasetofenon Menggunakan Metode Brine Shrimp Lethality Test (BSLT). Jurnal Photon Vol. 6 No.1.

[4] Chen, Y.H., Wang, W.H., Lin, Z.Y and Chern, C.Y. 2013. Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model. Molecules. 18: 2052-2060.

[5] Lusrianti, Nur Balatif dan Adel Zamri. 2015. Sintesis dan Uji Toksisitas Senyawa Analog Kalkon dari 4’- Hidroksiasetofenon dengan Dimetoksibenzaldehid. Jurnal Photon Vol. 6 No.1.

[6] Mega Cahayani, Agung Rahmadani, Dewi Rahmawati, Rolan Rusli. 2018. Sintesis dan Uji Toksisitas Senyawa 2’,4’-Dikloro-4-Metoksikalkon. Jurnal Ilmiah Manuntung, 4(2), 84-88.

Downloads

Published

2020-02-28

Issue

Vol. 11 (2020)

Section

Articles

License

Copyright (c) 2020 Amanuddin , Hanggara Arifian, Agung Rahmadani, Rolan Rusli (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.