Analisis Parameter Kimia dan Toksisitas Akut Ekstrak Air Daun Mekai (Albertisia papuana Becc.) pada Ginjal Mencit

Abstract

Mecca leaf (Albertisia papuana Becc.) Is a plant that is used as a flavor enhancer by the Dayak Ethnic community in East Kalimantan. The purpose of this study was to determine the chemical parameter content of Pb and Cd metals in simplicia and mekai leaf water extracts and to find out the toxicity of mekai leaf water extracts on kidney, liver and spleen of mice. Measurement of chemical parameters namely Pb and Cd metal levels in simplicia and water extracts using atomic absorption spectroscopy (AAS / AAS) and acute toxicity of water extracts of mekai leaves was done in vivo on test animals with dose variations of 0.105 mg, 2.1 mg, and 42 mg was given to test animals, pharmacological screening was observed, proteinuria levels were carried out using NOVA test® strips, body weight and organ index of mice. The results of measurements of Pb and Cd metal levels in simplicia and extracts of water contained lead as much as 0.851 ppm and 0.642 ppm (<0.10 ppm) and cadmium as much as 0.220 ppm and 0.027 ppm (<0.3 ppm). The result of the toxicity of mekai leaf water extract has LD₅₀>42 mg non-toxic to experimental animals and can stimulate the effects of the central nervous system on experimental animal behavior. So it can be concluded that simplicia and water extract of mekai leaves have Pb and Cd metal content below standard and can stimulate the central nervous system of experimental animals.