Kajian In Silico Senyawa Turunan Kalkon sebagai Antikanker

Authors

  • Riska Oktaviani Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Hanggara Arifian Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Agung Rahmadani Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Nur Masyithah Zamruddin Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
  • Rolan Rusli Kelompok Bidang Ilmu Kimia Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author https://orcid.org/0000-0003-1264-5933

DOI:

https://doi.org/10.30872/mpc.v9i.374

Keywords:

Kalkon, Antikanker, Topoisomerase, 3,4-metilendioksi asetofenon

Abstract

Senyawa kalkon termasuk dalam famili flavonoid yang memiliki aktivitas seperti antimalarial, antioksidan, antimikroba, antikanker dan analgesik. Aktivitas antikanker senyawa kalkon berbasis 3,4-metilendioksi asetofenon di analisis melalui metode docking dengan adanya interaksi antara senyawa turunan kalkon dengan enzim topoisomerase II. Senyawa turunan kalkon berbasis 3,4-metilendioksi asetofenon dioptimasi dengan Hyperchem 8.0 dan di docking dengan MOE Chemical Computing Group. Interaksi antara senyawa turunan kalkon dengan enzim topoisomerase II berupa interaksi hidrogen dan arene hydrogen.

References

[1] WHO (diakses 06 November 2018). Cancer. http://www.who.int/cancer/en/

[2] Rahman, M. 2011. Chalcone : A Valueable Insight Into The Recent Advances And Potential Pharmacological Activities. Chemical Science Journal.

[3] Pingaew, R, et al. 2014. Synthesis, Biological Evaluation and Molecular Docking of Novel Chalcone-Coumarin Hybrids as Anticancer and Antimalarial Agents. European Journal of Medicinal Chemistry, 65-76.

[4] Prada-Gracia D. et al. 2016. Application of Computational Methods for Anticancer Drug Discovery, Design, and Optimization. Bol Med Hosp Infant Mex. http://dx.doi.org/10.1016/j.bmhimx.2016.10.006

[5] Jandial, Danielle D. Et al. 2014. Molecular Targeted Approaches To Cancer Therapy And Prevention Using Chalcones. Curr Cancer Drug Targets 14(2).

[6] Nath Dhar, Durga. 1981. The Chemistry of Chalcones and Related Compounds. SERBIULA (sistema Librum 2.0).

[7] Nitiss, J. L. 2009. Targetting DNA Topoisomerase II in Cancer Chemotherapy. Nature Reviews Cancer, 338-350.

[8] Cole JC, et al. 2005. Comparing protein-ligand docking programs is difficult. Proteins. Aug 15;60(3):325-32. Review. PubMed PMID: 15937897.

[9] Jadhav, Ahwini K, and Mohan Karupayyil. 2017. Molecular Docking Studies On Thirteen Fluoroquinolones With Human Topoisomerase II A And B. In Silico Pharmacology 5:4. Germany.

[10] Nasution, Mochammad, et al. 2016. Chalcone and Its Pyrazole Derivatives as Potential Plasmodium falciparum Lactate Dehydrogenase Inhibitor: In Silico Approach for New Antimalarial Drug. DOI:10.13140/RG.2.1.2887.3847.

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Published

2019-04-30

Issue

Vol. 9 (2019)

Section

Articles

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Copyright (c) 2019 Riska Oktaviani, Hanggara Arifian, Agung Rahmadani, Nur Masyithah Zamruddin, Rolan Rusli (Author)

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.